Chronic Kidney Disease

Study: Long-Term Darbepoetin Use Safe, Effective in Non-Dialysis CKD

Study: Long-Term Darbepoetin Use Safe, Effective in Non-Dialysis CKD

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Japanese post-marketing study identified no new safety concerns among patients with non-dialysis chronic kidney disease treated with darbepoetin alfa and followed up for 3 years.

Gastrointestinal Lesions Common in Patients With CKD Anemia

Gastrointestinal Lesions Common in Patients With CKD Anemia

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In a Spanish study, endoscopic evaluation of patients with CKD and anemia revealed that 68.2% of patients had at least 1 gastrointestinal lesion.

Diabetes Develops At a Higher Rate in the CKD Population

Diabetes Develops At a Higher Rate in the CKD Population

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New study reveals a type 2 diabetes incidence rate of 17.81 cases per 1000 person-years, a rate much higher than in the general population.

Febuxostat May Preserve Renal Function in Some CKD Subgroups

Febuxostat May Preserve Renal Function in Some CKD Subgroups

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Study of patients with CKD stage 3 and asymptomatic hyperuricemia showed that febuoxostat ameliorated the annual decline in eGFR vs placebo in those without proteinuria.

CKD Progression Linked to Sodium Chloride Level

CKD Progression Linked to Sodium Chloride Level

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Low serum sodium chloride concentrations are associated with an increased risk of renal function decline events, especially among patients with CKD stage G4 and anemic patients.

Report: CKD Does Not Preclude Plant-Based Diets

Report: CKD Does Not Preclude Plant-Based Diets

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Concerns about nutritional deficiency in CKD patients are unfounded, and plant-based diets may actually be good for them, the authors of a new report contend.

Accuracy of 24-Hour Urine Phosphorus Challenged

Accuracy of 24-Hour Urine Phosphorus Challenged

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A new study found that 24-hour urine phosphorus is inversely related to whole-body retention, but is not related to net intestinal absorption.

Acute Renal Failure in CKD Patients Less Likely With PCI

Acute Renal Failure in CKD Patients Less Likely With PCI

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In a study, percutaneous coronary intervention was associated with a 72% decreased risk of acute renal failure compared with coronary artery bypass grafting in patients with chronic kidney disease.

Vitamin D Stores Lower in the Obese, Overweight

Vitamin D Stores Lower in the Obese, Overweight

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Obese or overweight individuals have significantly lower levels of 25-hydroxyvitamin D than normal-weight individuals at any level of kidney function, a study found.

Correcting Metabolic Acidosis May Preserve Muscle Mass

Correcting Metabolic Acidosis May Preserve Muscle Mass

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Oral sodium bicarbonate treatment was associated with improved lean body mass and kidney function in patients with metabolic acidosis due to CKD stages 3 and 4.

Single-Dose Potassium-Lowering Drug Effective in CKD, ESRD

Single-Dose Potassium-Lowering Drug Effective in CKD, ESRD

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A single 30-gram oral dose of sodium polystyrene sulfonate resulted in a significant decrease in serum potassium within 24 hours.

Stroke, Death Risk Increase With CKD and AFib

Stroke, Death Risk Increase With CKD and AFib

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Atrial fibrillation may up stroke risk as much as 1.5 to 2 times in CKD patients, according to study findings.

DOACs Increase Bleeding Risk More Than Warfarin in CKD

DOACs Increase Bleeding Risk More Than Warfarin in CKD

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DOAC users with eGFRs less than 60 mL/min/1.73m2 had a 23% higher risk for bleeding than warfarin users.

New Technique Allows Rapid Bedside Measurement of GFR

New Technique Allows Rapid Bedside Measurement of GFR

VFI approach for direct measurement of glomerular filtration rate is accurate and reproducible.

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Decline in rates of cardiac stress testing in Medicare beneficiaries aged 66 years from 2008 to 2012.

CKD Patients Often Excluded From Cancer Trials

CKD Patients Often Excluded From Cancer Trials

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Even patients with mild chronic kidney disease were prevented from participating in clinical trials of drugs for bladder, breast, colorectal, lung, and prostate cancers.

Daily Coffee Drinking May Prevent CKD

Daily Coffee Drinking May Prevent CKD

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Drinking one cup of coffee daily was associated with 24% lower risk for chronic kidney disease.

CKD Prevalence, Progression Rate High Among Elderly Diabetics

CKD Prevalence, Progression Rate High Among Elderly Diabetics

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In a South Korean study, nearly 60% of elderly patients with type 2 diabetes had chronic kidney disease at baseline.

Low-Level Lead Exposure Found to Increase CKD Risk

Low-Level Lead Exposure Found to Increase CKD Risk

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Individuals with higher blood lead levels experienced greater decreases in eGFR.

Substance Use Ups Risks for CKD Progression, Mortality

Substance Use Ups Risks for CKD Progression, Mortality

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Persistent cocaine use by patients with chronic kidney disease more than doubled their risk for death.

FGF23 Predicts Development of CKD Anemia

FGF23 Predicts Development of CKD Anemia

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Anemia is 66% and 84% more likely to develop among patients in the 3rd and 4th quartiles of serum fibroblast growth factor 23 level vs those in the 1st quartile.

Studies Provide Detailed Look at Treatment-Related Hyperkalemia

Studies Provide Detailed Look at Treatment-Related Hyperkalemia

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Rates of hyperkalemia associated with receipt of renin-angiotensin-aldosterone system inhibitors vary by age and comorbidities.

Preeclampsia Increases Kidney Disease Risk Post-Pregnancy

Preeclampsia Increases Kidney Disease Risk Post-Pregnancy

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The risk of chronic kidney disease among women who experience preeclampsia is particularly elevated within 5 years of delivery.

Hyperkalemia Common in Stages 2-5 CKD

Hyperkalemia Common in Stages 2-5 CKD

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Longitudinal study with preplanned serum potassium measurements may provide a more accurate estimate of the burden of hyperkalemia among CKD patients.

Bardoxolone Shows Promise for ADPKD

Bardoxolone Shows Promise for ADPKD

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In a phase 2 trial that enrolled 31 patients with autosomal dominant polycystic kidney disease, treatment with bardoxolone resulted in a significant increase in kidney function.

Midstream Urine Microbiome Diverse in Seniors With CKD

Midstream Urine Microbiome Diverse in Seniors With CKD

After adjustment for demographics and diabetes status, microbiome diversity linked to estimated GFR.

Increasing Water Intake Does Not Slow eGFR Decline in CKD

Increasing Water Intake Does Not Slow eGFR Decline in CKD

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A nonsignificant 0.3 mL/min/1.73 m2 difference in eGFR was found between the usual and increased water intake groups after 1 year.

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.

Sleep Duration Tied With Quality of Life in CKD

Sleep Duration Tied With Quality of Life in CKD

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Patients with chronic kidney disease who sleep 7 hours a night have the highest health-related quality of life, new study finds.

Tolvaptan Cleared in US for ADPKD in Adults

Tolvaptan Cleared in US for ADPKD in Adults

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Originally approved for hyponatremia, the medication is the first FDA-approved treatment for rapidly progressing autosomal dominant polycystic kidney disease in adults.

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